Organic Synthesis
Code
8807
Academic unit
Faculdade de Ciências e Tecnologia
Department
Departamento de Química
Credits
4.0
Teacher in charge
Paula Cristina de Sério Branco
Weekly hours
2
Total hours
35
Teaching language
Português
Objectives
It is intended that the student develop the capacity to plan strategies for the efficient synthesis of simple organic molecules, being able to compare them from an overall yield and strategic point of view.
Prerequisites
Basic knowledge in organic chemistry. Stereochemistry. Functional group recognition and chemistry.
Subject matter
General concepts involved in a chemical synthesis. Synthetic strategy. Linear synthesis and convergent synthesis. Synthetic yield. Economy of atoms. The problem of waste. Emergence of concepts of ‘green’ chemistry.
Retrosynthetic analysis: general concepts of retrosynthesis. Disconnection, synthon, equivalent synthon, control synthon, functional group interconvertion, ‘umpolung’. Disconnection of one or more functional groups.
Retrosynthesis and synthesis of alicyclic compounds containing heteroatoms (N, S, O).
Methods for the obtention of compounds bearing 3- and 4-membered rings. Brief mention to the synthesis of heterocycles.
Bibliography
- S. Warren. Organic Synthesis - The disconnection Approach. Wiley 1982.
- J. Clayden, N. Greeves, S. Warren and P. Wothers. Organic Chemistry. Oxford University Press, 2001.
- P. Wyatt, S Warren,Organic Synthesis - Strategy and Control. Wiley, 2007.
- S. Prabhakar (ed.), Organic Synthetic Methodology, Edinova, Lisboa, 2000.
Teaching method
Lectures will be given with the help of the data show involving great interactivity professor-student.
Evaluation method
Continuous assessment with tests of short duration (35%) and Final exam (65%).