Innovative Medicines Initiative (IMI, Iniciativa sobre Medicamentos Inovadores) 

Os 18 tópicos científicos que foram abertos a concurso em 2008 foram:

  • SAFETY (Improve the predictivity of safety evaluation during the research and development process)

  1. Improve Predictivity and Minimization Strategies of Immunogenicity for biotherapeutics in Man
  2. Non-genotoxic carcinogenesis: Identification of early markers and molecular classification of tumours
  3. Development of expert (QSAR) systems for in silico toxicity prediction
  4. Improved Predictivity of Non-Clinical Safety Evaluation
  5. Qualification of Translational Safety Biomarkers from Non Clinical to Early Clinical Studies
  6. Improving and strengthening the monitoring of the benefit/risk of medicines marketed in the EU

  • EFFICACY (Address bottlenecks related to predictive pharmacology, the identification and validation of biomarkers and patient recruitment)

  1. Islet cell research: Improving β-cell function and identification of diagnostic biomarkers for treatment monitoring in diabetes
  2. Surrogate markers for micro- and macrovascular hard endpoints to shorten clinical trials on diabetes
  3. Pain research: Innovative preclinical and clinical rapprochement to produce biomarkers for safer and more effective treatments
  4. New tools for the development of novel therapies in psychiatric disorders
  5. Neurodegenerative disorders : Bridging the preclinicalclinical divide
  6. Understanding Severe Asthma, the fundamental bottleneck to advancing new medicines for the syndrome
  7. COPD Patient Reported Outcomes (PROs), a major bottleneck to understanding patient and economic benefits of new therapies

  • EDUCATION & TRAINING (Address the gaps within education and training in support of the medicines development process)

  1. Establishment of a network to facilitate and coordinate European training and education relevant for stakeholders of medicines research and development
  2. IMI Safety Sciences for Medicines Training Programme
  3. IMI Pharmaceutical Medicine Training Programme
  4. IMI Integrated Medicines Development Course Programme for non-specialists
  5. IMI Pharmacovigilance Training Programme
 
Mais informações:
 

A Plataforma Portuguesa de Apoio à IMI (lançada pela Apifarma, Infarmed e Health Cluster Portugal, mas aberta à integração de novos membros) tem como objectivo majorar a participação portuguesa na IMI, ajudando os interessados a participar no maior número possível de consórcios concorrentes aos 18 tópicos do concurso de 2008. Para a sistematização dos interesses nacionais está disponível um portal Web sediado na Reitoria da Universidade do Porto.

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